Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
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چکیده
منابع مشابه
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes
The depletion of intracellular Ca2+ stores triggers the opening of Ca2+ release-activated Ca2+ (CRAC) channels in the plasma membrane of T lymphocytes. We have investigated the additional role of extracellular Ca2+ (Ca02+) in promoting CRAC channel activation in Jurkat leukemic T cells. Ca2+ stores were depleted with 1 microM thapsigargin in the nominal absence of Ca02+ with 12 mM EGTA or BAPTA...
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متن کاملMonovalent Permeability, Rectification, and Ionic Block of Store-operated Calcium Channels in Jurkat T Lymphocytes
We used whole-cell recording to characterize ion permeation, rectification, and block of monovalent current through calcium release-activated calcium (CRAC) channels in Jurkat T lymphocytes. Under physiological conditions, CRAC channels exhibit a high degree of selectivity for Ca2+, but can be induced to carry a slowly declining Na+ current when external divalent ions are reduced to micromolar ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1996
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.107.5.597